Below you will find preprints and peer-reviewed publications as part of our IMAGINE! project.
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Preprints (awaiting peer-review)
Taxane-induced conformational changes in the microtubule lattice activate RhoA signaling (2025). Meiring Joyce C. M. et al. bioRxiv Preprint. DOI: 10.64898/2025.12.20.695343. URL: http://biorxiv.org/lookup/doi/10.64898/2025.12.20.695343
Immortalization of human nasal and bronchial airway epithelial cells for genome editing applications (2025). Van Grinsven Emma J. et al. bioRxiv Preprint. DOI: 10.1101/2025.11.30.691384. URL: http://biorxiv.org/lookup/doi/10.1101/2025.11.30.691384
Active learning-guided mechanistic modeling of CXCL9 regulation in pancreatic cancer (2025). Wang B. et al. bioRxiv Preprint. DOI: 10.1101/2025.10.24.684332. URL: http://biorxiv.org/lookup/doi/10.1101/2025.10.24.684332
Microtubule organization and molecular architecture of ciliary basal bodies in multiciliated airway cells (2025). Van Grinsven Emma J. et al. bioRxiv Preprint. DOI: 10.1101/2025.09.04.674302. URL: http://biorxiv.org/lookup/doi/10.1101/2025.09.04.674302
SSNA1 organizes the distal luminal centriolar network and promotes ciliogenesis without microtubule association (2025). Huang Yi-Chi et al. bioRxiv Preprint. DOI: 10.1101/2025.04.28.648957. URL: https://doi.org/10.1101/2025.04.28.648957
Patterned illumination enables denser deep-learning based single-molecule localization microscopy (2025). Cnossen J et al. bioRxiv Preprint. DOI: https://doi.org/10.1101/2025.03.09.642203
Small molecule-directed differentiation of submerged-cultured human nasal airway epithelia for respiratory disease modelling (2024). Dreyer Henriette H.M. et al. bioRxiv Preprint. DOI: 10.1101/2024.10.17.618953. URL: https://doi.org/10.1101/2024.10.17.618953
Publications
2026
Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway (2026). Plugge S.F. et al. Gastroenterology. DOI: 10.1053/j.gastro.2025.07.041. URL: https://doi.org/10.1053/j.gastro.2025.07.041
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma (2026) G. A. Franken et al. Molecular Oncology. DOI: 10.1002/1878-0261.70182. URL: https://doi.org/10.1002/1878-0261.70182
2025
Closed-loop optogenetic control of cell biology enables outcome-driven microscopy (2025) Passmore JB et al. Nat Commun. 2025;17:1087.DOI: 10.1038/s41467-025-67848-5
Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body (2025). Berrevoets Enya S. et al. Nat Commun 16, 10689 URL: https://doi.org/10.1038/s41467-025-65723-x
Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments (2025). Zegers Mirjam M. et al. Cold Spring Harbor Perspectives in Biology. DOI: 10.1101/cshperspect.a041794. URL: https://doi.org/10.1101/cshperspect.a041794
Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state (2025). Van Der Net Mirjam C. et al. Cell Reports. DOI: 10.1016/j.celrep.2025.116308. URL: https://doi.org/10.1016/j.celrep.2025.116308
CD151 interacts with integrin beta 2 in B cell lymphomas (2025). Hagemann Philipp M. et al. Cellular and Molecular Life Sciences. DOI: 10.1007/s00018-025-05747-0. URL: https://doi.org/10.1007/s00018-025-05747-0
Strategies for overcoming ABC‑transporter‑mediated drug resistance (2025). de Groot et al. AJP Cell Physiol. DOI: 10.1152/ajpcell.00412.2025. URL: https://doi.org/10.1152/ajpcell.00412.2025
Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients (2025). Buissant des Amorie et al. Nature communications. DOI: 10.1038/s41467-025-61878-9. https://doi.org/10.1038/s41467-025-61878-9
BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation (2025). El Bouazzaoui Layla et al. iScience. DOI: 10.1016/j.isci.2025.112708. URL: https://doi.org/10.1016/j.isci.2025.112708
Co-delivery of antigen and adjuvant by site-specific conjugation to dendritic cell-targeted Fab fragments potentiates T cell responses (2025). Wijfjes Zacharias et al. RSC Chemical Biology. DOI: 10.1039/D5CB00014A. URL: https://doi.org/10.1039/D5CB00014A
Resolution in super-resolution microscopy – facts, artifacts, technological advancements and biological applications. (2025) Prakash K, Baddeley D, Eggeling C, Fiolka R, Heintzmann R, Manley S, Radenovic A, Shroff H, Smith C, Schermelleh L. J Cell Sci. 2025;138:jcs263567. DOI:https://doi.org/10.1242/jcs.263567
An algorithmic perspective on deciphering cell–cell interactions with spatial omics data (2025). van Santvoort Maxime, Eduati Federica. Briefings in Bioinformatics. DOI: 10.1093/bib/bbaf236. URL: https://doi.org/10.1093/bib/bbaf236
Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments (2025). Pasolli Milena et al. J Cell Biol. DOI: 10.1083/jcb.202504004. URL:
https://doi.org/10.1083/jcb.202504004
Mathematically mapping the network of cells in the tumor microenvironment (2025). van Santvoort Maxime et al. Cell Reports Methods. DOI: 10.1016/j.crmeth.2025.100985. URL: https://doi.org/10.1016/j.crmeth.2025.100985
Diversity of microtubule arrays in animal cells at a glance (2025). Van Grinsven, Emma J. and Akhmanova, Anna Journal of Cell Science. DOI: 10.1242/jcs.263476. URL: https://doi.org/10.1242/jcs.263476
The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy (2025). Bornes, Laura et al, Nature. DOI: 10.1038/s41586-024-08276-1. URL: https://doi.org/10.1038/s41586-024-08276-1
2024
Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study (2024). Lapuente-Santana Óscar, Kant Joan, Eduati Federica. npj Precision Oncology. DOI: 10.1038/s41698-024-00749-w. URL: https://doi.org/10.1038/s41698-024-00749-w
Multiphoton fluorescence microscopy for in vivo imaging (2024) Xu C et al. Cell. 187:4458-87. https://doi.org/10.1016/j.cell.2024.07.036
Oriented Antibody Coupling to an Antifouling Polymer Using Glycan Remodeling for Biosensing by Particle Motion (2024). Linssen, Maud D. M. E. et al, Bioconjugate Chemistry. DOI: 10.1021/acs.bioconjchem.4c00196. URL: https://doi.org/10.1021/acs.bioconjchem.4c00196
A Photocaged Microtubule‐Stabilising Epothilone Allows Spatiotemporal Control of Cytoskeletal Dynamics (2024). Schmitt Carina et al. Angewandte Chemie International Edition. DOI: 10.1002/anie.202410169. URL: https://doi.org/10.1002/anie.202410169
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors (2024). Bugter Jeroen M. et al. Life Science Alliance. DOI: 10.26508/lsa.202402575. URL: https://doi.org/10.26508/lsa.202402575
Image scanning microscopy: a vectorial physical optics analysis. (2024) Hung ST, Kalisvaart D, Smith C. Opt Express. 2024;32:1524-39 URL: https://doi.org/10.1364/OE.500957
2023
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance (2023). Van Der Krift Felix et al. Life Science Alliance. DOI: 10.26508/lsa.202302058. URL: https://doi.org/10.26508/lsa.202302058
Bilayer Microfluidic Device for Combinatorial Plug Production (2023). Yelleswarapu Maaruthy et al. Journal of Visualized Experiments. DOI: 10.3791/66154. URL: https://doi.org/10.3791/66154
Acknowledgement
Written acknowledgement text:
This work was supported by the Netherlands Organization for Scientific Research (NWO) Gravitation programme IMAGINE! (project number 24.005.009).